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The investigators interpreted the effects as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in genetic models

Plasma PYY 336 concentrations rise within 15 min of food ingestion, well before nutrients reach the colon or rectum where it is released, implicating a neural or hormonal mechanism for its release [9]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 112.Ibrahim ZA, Hassan GF, Elgendy HY, Al-Shenawy HA