Results showed that people taking Wegovy pill once-daily along with a reduced calorie diet and exercise achieved an average weight loss of about 14% (13.6%) versus 2.4% with placebo
So, pharmaceutical companies started investigating the use of GLP-1s for weight-management purposes, and the first GLP-1 weight-loss drug, Saxenda (liraglutide), was approved by FDA in 2014 (it was previously approved to treat diabetes under the name Victoza)
Factors to Consider When Choosing a GLP-1 Agonist Your Goals: For significant weight loss, options like semaglutide or tirzepatide are most effective
Side effects from GLP-1 medications are deeply personal and can vary dramatically from person to person
Currently, liraglutide, semaglutide, and tirzepatide are FDA-approved for obesity treatment, while other agents are used off-label
The compound matters semaglutide and tirzepatide carry different economics