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Repeated injections into the same spot cause scar tissue and lipohypertrophy, both of which reduce B12 absorption over time

The EFSA notes, The inherent uncertainty of this [factorial] approach is reflected in the wide range of cobalamin intake calculated to compensate for estimated daily losses, depending on the assumptions taken (EFSA, 2015). Appendix D

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The intrinsic factor then binds with B12, facilitating the uptake of B12 in the small intestines.[ref] Without intrinsic factor, you cant absorb B12 from animal proteins

That same person on retatrutide 12 mg would lose approximately 72 pounds, ending at roughly 178 pounds