A commenter stated that the lack of comprehensive impact analysis on different geographic regions, practice types, and patient populations represents a significant oversight that could lead to unintended access problems and practice closures in areas where healthcare resources are already scarce
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Andres Salumets: Conceptualization, Supervision, Resources, Writingoriginal draft, Writingreview & editing
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Supported by review consolidation of in vitro and animal evidence, but not yet by direct human dermal histology comparing pre- and post-GLP-1 skin samples
Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes
