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Amphetamines can also increase the release of excess glutamate from nerve endings of the CNS into the cortex, resulting in an imbalance of cortical signaling

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However, to our knowledge, there are no previous reports using this approach to measure glutathione in CSF

Interestingly, genetic mutations in sALS patients have also been described, in C9orf72 (7% of cases), TARDBP, SOD1, FUS, VCP, p62, PFN-1 , MATR3, OPTN, UBQLN2 , CHCHD10, TBK1 , TUBA4A, NEK1, C21orf2 , and CCNF , together accounting for 15% of sporadic ALS cases (Taylor et al., 2016

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