clinical trials tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo- controlled, phase 3 trial Tirzepatide: First Approval | Drugs

[2] For most patients, according to NICE guidance (NG28), the benefits of improved glycaemic control with Ozempic may outweigh the potential risks, particularly in those with established cardiovascular disease

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Hormonal Stability Many weight loss approaches disrupt multiple hormonal axes, creating cascading effects on appetite, stress response, thyroid function, and reproductive hormones

Managing gastrointestinal side effects: Tirzepatide can sometimes cause nausea or stomach discomfort, especially when initiating or increasing your dose

De Graaf C, Donnelly D, Wootten D et al (2016) Glucagon-like peptide-1 and its class B G protein-coupled receptors: a long march to therapeutic successes

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