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In contrast, lysosomes maintained their largely peripheral distribution in TMEM55B or TBC1D9B KO cells (Fig

Cells 12 , 926 (2023)

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The first phase is the direct stimulation of sensory nerve endings by formalin, which causes acute pain as an inflammatory response, and the second phase causes persistent pain by central sensitization

Any significant changes in mood, anxiety levels or emotional wellbeing should be discussed with a healthcare professional promptly