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(2023) found that GLP-1 receptor agonists reduced the risk of lower limb amputation by 43% compared to sulfonylureas (HR: 0.57, 95% CI: 0.390.84), with the greatest risk reduction observed in long-term users (HR: 0.44, 95% CI: 0.270.72).(26) However, GLP-1 receptor agonists did not significantly impact diabetic foot ulcer incidence (HR: 1.08, 95% CI: 0.871.35)

Bioorg Med Chem 21:70647073 Druce MR, Minnion JS, Field BC et al (2009) Investigation of structure-activity relationships of Oxyntomodulin (Oxm) using Oxm analogs

rather, it reflects how strongly GLP-1 receptors affect gastric emptying and gut motility before the body has time to adapt

In trials, tirzepatide showed it could help people lose up to 22.5% of their total body weight

If you are considering a GLP-1 medication for weight loss , you may know that dehydration is a possibility