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The accumulation and metabolism of drugs in the liver can cause a variety of pathophysiologic complications that often go undiagnosed as DILI

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Chronic Disease Management Glutathione deficiency may be caused by HIV/AIDS, cancer, type 2 diabetes, Parkinson's disease, or hepatitis conditions that both deplete glutathione and are worsened by its depletion

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Apart from the well-documented GPx-like catalytic activity, ebselen is also reported for directly scavenging the biologically relevant ROS (like peroxyl and singlet oxygen) and reactive nitrogen species (peroxynitrite) with rate constants comparable to standard antioxidants