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Carnitine deficiency impairs the mitochondrial -oxidation of FAs, leading to acute metabolic decompensation, elevated aminotransferase, and hepatic encephalopathy similar to NAFLD (75)

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Semaglutide carries important safety warnings, including a boxed warning for medullary thyroid carcinoma (MTC) risk and contraindications for patients with personal/family history of MTC or Multiple Endocrine Neoplasia syndrome type 2

Recently, the concept of a "metabolic diapause" has been proposed for the changes induced by FoxO1 to protect -cells against oxidative stress underpinning the concept of -cell rest as a treatment goal in T2D [11]

Each of these substances is fat-soluble and, unlike water-soluble vitamins, accumulates rapidly in the body, particularly in the adipose tissue and liver

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