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The drop in HO-1 levels after treatment with NAC indicates that the low content of Nrf2 is associated with a reduced ability of this transcription factor to induce production of antioxidant enzymes by pituitary cells

Withanolides are known to engage with GABAergic and serotonergic pathways, which mitigates the hyperactivation of the HPA axis, resulting in enhanced stress tolerance and anxiolytic effects (78)

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Additionally, updates in insurance coverage have made these medications more accessible to patients with qualifying conditions

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