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There are several underlying reasons for the methyl trap: the concentration of Hcy drops, oxidative stress inhibits MS, and the drop in [SAM] releases the inhibition of MTHFR, which drives more folate towards the 5mTHF form

The high-dose group (1000 mg/day) achieved a 31% increase in whole blood and a 35% increase in erythrocytes

and Moss, P., Canadian Journal of Psychiatry , 2012, vol

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