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As a result, safinamide has demonstrated dual efficacy in reducing OFF time, increasing ON time, and improving non-motor symptoms such as pain, sleep disturbances, and mood disorders

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A recent longitudinal metabolomic study comparing newborn and 5-year-old ASD patients revealed that the majority of the metabolic differences in ASD patients were accounted for by 14 key biochemical pathways [315]

Activation of GPX4 partially rescued these effects, reinforcing the role of mGPDH as an auxiliary mitochondrial defense mechanism against ferroptosis under pathological stress

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A recent study conducted by Greenway et al