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The role of zonulin in T1D was further reinforced by Watts and colleagues who demonstrated that T1D-associated symptoms could be alleviated in disease-prone rodent models following administration of a zonulin inhibitor (Watts et al

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The disruption of the nuclear transporter ZIP11 causes nuclear zinc to accumulate, impairing cell proliferation, delaying cell-cycle progression and triggering senescence pathways 37

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Research on nanocarrier systems (PMID: 38394858) has explored rigid-flexible nanocarriers for enhanced topical delivery of the peptide

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doi:10.3748/wjg.v21.i29.8787 17

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