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Pyridoxine (B6) can reduce the effect of levodopa when levodopa is given without a peripheral decarboxylase inhibitor

The formulation and excipients in B12 supplements often play a significant role

Mood Enhancement A deficiency in B12 is linked to mood disorders such as depression and anxiety

91 In a three-month trial, 90 subjects with tinnitus were treated with ginkgo extract (60 mg twice daily), betahistine (Serc), or trimetazidine (Vastarel) (a drug that dilates coronary and other peripheral blood vessels, but is not available in the United States)

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Dosage Adjustments Based on Clinical Response Adjusting the dosage is a big part of treating vitamin B12 deficiency