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In addition, there was a modest statistically significant association for stroke/TIA and a suggestive, non-significant trend for MI, while coronary revascularization and hospitalization were not significantly reduced

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As hypothesized, this modification resulted in reduced internalization at the GLP-1R

It has not been associated with the more serious potential complications of pharmaceutical GLP-1 agonists, such as pancreatitis or gallbladder problems

Large meals late at night can cause discomfort due to slowed gastric emptying

Given the crucial role of protease-specific PAR2 signaling in regulation of postprandial GIP, we next conducted DIO studies in PAR2-G37I and PAR2-R38E mutant mice