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Its benefits are real but more subtle, making it not a direct substitute
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In IL-1-stimulated OA models, they upregulate SOX9 and COMP while suppressing ADAMTS4 activity, and micro-CT analysis shows 35% less subchondral bone loss
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Though there has been some preliminary data that GLP-1RAs might protect against cognitive decline and dementia, the research is still in clinical trials
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