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AEF0117 inhibited THC-induced p-ERK1/2 in both cell lines with similar potency (IC 50 300 nM), but the extent of inhibition was more pronounced in STHdh Q7/Q7 cells (Extended Data Fig

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Whilst standard therapeutic doses of semaglutide or liraglutide are carefully calibrated through extensive clinical trials, microdosing involves using a fraction of these established dosesoften below licensed starting doses